Known targets — ChEMBL curated mechanism
TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8
The experimentally established mechanism targets of Vinflunine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 6/20 | 0.77 |
| ▸ | TUBB known ✓ | P07437 | 6/20 | 0.77 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 6/20 | 0.77 |
| ▸ | TUBA1B known ✓ | P68363 | 6/20 | 0.77 |
| ▸ | TUBA4A known ✓ | P68366 | 6/20 | 0.77 |
| ▸ | TUBB4B known ✓ | P68371 | 6/20 | 0.77 |
| ▸ | TUBB3 known ✓ | Q13509 | 6/20 | 0.77 |
| ▸ | TUBB2A known ✓ | Q13885 | 6/20 | 0.77 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 6/20 | 0.77 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 6/20 | 0.77 |
| ▸ | TUBA1A known ✓ | Q71U36 | 6/20 | 0.77 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 6/20 | 0.77 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 6/20 | 0.77 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 6/20 | 0.77 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vinflunine SCHEMBL10018503 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL29379199 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL16886954 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL8403 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL19242433 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL16786354 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL21090975 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL21449088 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL21050493 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Vinflunine SCHEMBL16766896 | 1.00 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168647-B2 | Vinblastine derivatives, their preparation, use and pharmaceutical compositions comprising the said derivatives | SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES (CN) | 2012-05-01 | — | — | US | disclosed |
| US-20100113498-A1 | NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113498-A1 | NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES | MCL1, BAX, BAD | TUBB4A 152/4885TUBB 95/4885TUBA3C 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.