⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25714927 | 0.82 | CHRM2 (0.31) | — | |
| SCHEMBL14214213 | 0.81 | — | — | |
| SCHEMBL16492821 | 0.79 | — | — | |
| SCHEMBL13989001 | 0.79 | — | — | |
| SCHEMBL14050512 | 0.77 | — | — | |
| SCHEMBL14050511 | 0.77 | CA2 (0.33) | — | |
| SCHEMBL24221262 | 0.76 | ALOX5 (0.32) | — | |
| SCHEMBL18681400 | 0.75 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL888758 | 0.74 | HPGD (0.45) | — | |
| SCHEMBL888750 | 0.74 | HPGD (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787788-B2 | Benzimidazole derivatives, and pharmaceutical compositions and methods of use thereof | CAPELLA THERAPEUTICS, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-11713322-B2 | Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer | CAPELLA THERAPEUTICS, INC. (US) | 2023-08-01 | — | — | US | disclosed |
| US-20230212164-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-07-06 | — | — | US | disclosed |
| US-20180134684-A1 | METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180009779-A1 | METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-01-11 | — | — | US | disclosed |
| US-20170183330-A1 | BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | CAPELLA THERAPEUTICS, INC. (US) | 2017-06-29 | — | — | US | disclosed |
| US-20170174697-A1 | BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | CAPELLA THERAPEUTICS, INC. | 2017-06-22 | — | — | US | disclosed |
| US-20170088582-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS, INC. (US) | 2017-03-30 | — | — | US | disclosed |
| US-20170037085-A1 | PEPTIDOMIMETIC COMPOUNDS | NOLIVA THERAPEUTICS LLC (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170037085-A1 | PEPTIDOMIMETIC COMPOUNDS | NOLIVA THERAPEUTICS LLC (US) | 2017-02-09 | — | — | US | disclosed |
| US-9493510-B2 | Peptidomimetic compounds | NOLIVA THERAPEUTICS LLC (US) | 2016-11-15 | — | — | US | disclosed |
| US-9493510-B2 | Peptidomimetic compounds | NOLIVA THERAPEUTICS LLC (US) | 2016-11-15 | — | — | US | disclosed |
| WO-2016050209-A1 | HETEROFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD, AND BIO-RELATED SUBSTANCE | 厦门赛诺邦格生物科技有限公司 | 2016-04-07 | — | — | WO | disclosed |
| US-20150353606-A1 | PEPTIDOMIMETIC COMPOUNDS | NOLIVA THERAPEUTICS LLC (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150353606-A1 | PEPTIDOMIMETIC COMPOUNDS | NOLIVA THERAPEUTICS LLC (US) | 2015-12-10 | — | — | US | disclosed |
| US-8110211-B2 | Medicated coatings for implantable medical devices including polyacrylates | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20100298270-A1 | Novel Compounds and Methods of Using Them | SYNDAX PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | US | disclosed |