SCHEMBL10050483

SCHEMBL10050483

N#Cc1nc2nc3c(nc2nc1C#N)-c1ccccc1C3=O

nearest known ligand 0.83

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
USP8 P40818 15/20 0.83
USP7 Q93009 9/20 0.83
USP47 Q96K76 4/20 0.83
MAPT P10636 2/20 0.55
RAB9A P51151 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
NPC1 O15118 1/20 0.55
ALDH1A1 P00352 1/20 0.55
AHR P35869 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1512485 0.91 USP8 (1.00) USP8USP7USP47MAPTRAB9A
SCHEMBL30931160 0.91 USP8 (1.00) USP8USP7USP47MAPTRAB9A
SCHEMBL1512515 0.87 USP8 (0.92) USP8USP7USP47MAPTRAB9A
SCHEMBL1512546 0.80 USP8 (1.00) USP8USP7USP47MAPTRAB9A
SCHEMBL1512518 0.80 USP8 (0.78) USP8USP7USP47MAPTRAB9A
SCHEMBL1512371 0.80 USP8 (0.78) USP8USP7USP47MAPTRAB9A
SCHEMBL8487532 0.80 USP8 (0.78) USP8USP7USP47MAPTRAB9A
SCHEMBL1512437 0.76 USP8 (0.71) USP8USP7USP47MAPTRAB9A
SCHEMBL13751740 0.76 USP8 (0.71) USP8USP7USP47MAPTRAB9A
SCHEMBL1512570 0.76 USP8 (0.71) USP8USP7USP47MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119828-B2 Material for an organic electroluminescence device and an organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2012-02-21 US disclosed
US-8119828-B2 Material for an organic electroluminescence device and an organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2012-02-21 US disclosed
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-02-25 US disclosed
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-02-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE AFF4, KCNH3, HCN4 USP8 4307/4885USP7 4265/4885USP47 4258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.