Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10052164 | 0.86 | TLR7 (0.48) | TLR7KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10052241 | 0.84 | TLR7 (0.47) | TLR7KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27830319 | 0.84 | TLR7 (0.54) | TLR7KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL314037 | 0.79 | TLR7 (0.53) | TLR7HDAC1HDAC8HDAC6SLC6A3 | |
| SCHEMBL13475954 | 0.78 | TLR7 (0.53) | TLR7KMT2ACNR2ALDH1A1MAPT | |
| SCHEMBL5512650 | 0.76 | TLR7 (0.50) | TLR7KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL1669181 | 0.76 | KMT2A (0.52) | KMT2ACNR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4455537 | 0.76 | KMT2A (0.52) | KMT2ACNR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21495006 | 0.76 | HDAC1 (0.42) | TLR7KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL13827949 | 0.75 | TLR7 (0.53) | TLR7KMT2AHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120009141-A1 | FUNCTIONALIZED PYRROLIDINES AND USE THEREOF AS IAP INHIBITORS | PHARMASCIENCE INC. (CA) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009141-A1 | FUNCTIONALIZED PYRROLIDINES AND USE THEREOF AS IAP INHIBITORS | BIRC5, BIRC7, BIRC2 | TLR7 3296/4885KMT2A 4154/4885HDAC1 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.