SCHEMBL1005309

SCHEMBL1005309

CCC([O])C(=O)O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1005300 0.75
SCHEMBL2174121 0.73
Ethylmalonate SCHEMBL107241 0.72
SCHEMBL1007264 0.71
SCHEMBL3710163 0.71
SCHEMBL29864869 0.71
SCHEMBL1730691 0.71
SCHEMBL29448832 0.71 ALDH1A1 (0.55)
SCHEMBL3511776 0.71
SCHEMBL5323 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 697 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220402897-A1 CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE HOFFMANN-LA ROCHE INC. (US) 2022-12-22 US claimed
CN-112839714-A Chromen-4-one derivatives for the treatment and prevention of hepatitis B virus diseases 豪夫迈·罗氏有限公司 2021-05-25 CN claimed
CN-107820496-B Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infections 豪夫迈·罗氏有限公司 2020-11-03 CN claimed
CN-107624113-B Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection 豪夫迈·罗氏有限公司 2020-10-23 CN claimed
WO-2020079106-A1 CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE F. HOFFMANN-LA ROCHE AG (CH) 2020-04-23 WO claimed
EP-3292120-B1 TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS HOFFMANN LA ROCHE (CH) 2019-06-19 EP claimed
EP-3328855-B1 NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION HOFFMANN LA ROCHE (CH) 2019-05-15 EP claimed
US-10053461-B2 Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection HOFFMANN-LA ROCHE INC. (US) 2018-08-21 US claimed
EP-3328855-A1 NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION H. Hoffnabb-La Roche Ag (CH) 2018-06-06 EP claimed
US-20180127416-A1 NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION HOFFMANN-LA ROCHE INC. (US) 2018-05-10 US claimed
US-20100317582-A1 NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2010-12-16 US claimed
EP-2234961-A2 NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2010-10-06 EP claimed
WO-2009065406-A2 NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES LEO PHARMA A/S (DK) 2009-05-28 WO claimed
US-20050137220-A1 Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors PHARMACIA CORPORATION (US) 2005-06-23 US claimed
US-5589315-A SHELF LIFE, SCREEN PRINTING TOYO GOSEI KOGYO CO., LTD. (JP) 1996-12-31 US claimed
EP-0712388-A1 USE OF PHENOLS AND PHENOL DERIVATES AS MEDICAMENTS WITH FIBRINOGEN-REDUCING EFFECT Roche Diagnostics GmbH (DE) 1996-05-22 EP claimed
US-5430130-A Photosensitive polyfunctional aromatic diazo compounds useful in photosensitive compositions TOYO GOSEI KOGYO CO., LTD. (JP) 1995-07-04 US claimed
WO-1995005358-A1 USE OF PHENOLS AND PHENOL DERIVATES AS MEDICAMENTS WITH FIBRINOGEN-REDUCING EFFECT BOEHRINGER MANNHEIM GMBH (DE) 1995-02-23 WO claimed
EP-0123902-B1 PROCEDURE FOR THE DETERMINATION OF PEROXIDASE ACTIVITY BY END DILUTION TITRATION AND MEANS FOR ITS REALIZATION Byk-Sangtec Diagnostica GmbH &amp; Co. KG (DE) 1991-09-18 EP claimed
EP-0123902-A2 Procedure for the determination of peroxidase activity by end dilution titration and means for its realization Byk-Sangtec Diagnostica GmbH &amp; Co. KG (DE) 1984-11-07 EP claimed