Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10057885 | 0.92 | ACE (0.55) | ACEKLK5L3MBTL1F2PRSS1 | |
| SCHEMBL572136 | 0.92 | ACE (0.55) | ACEKLK5L3MBTL1F2PRSS1 | |
| SCHEMBL572693 | 0.91 | ACE (0.49) | ACEKLK5L3MBTL1CTSSCTSK | |
| SCHEMBL14982904 | 0.91 | ACE (0.49) | ACEKLK5L3MBTL1CTSSCTSK | |
| SCHEMBL10057468 | 0.83 | CTSS (0.54) | ACEKLK5L3MBTL1CTSSCTSK | |
| SCHEMBL571640 | 0.83 | CTSS (0.54) | ACEKLK5L3MBTL1CTSSCTSK | |
| SCHEMBL571948 | 0.82 | REN (0.53) | ACEKLK5CTSSCTSKCTSL | |
| SCHEMBL10057469 | 0.82 | REN (0.53) | ACEKLK5CTSSCTSKCTSL | |
| SCHEMBL571617 | 0.80 | CMA1 (0.57) | ACEF2PRSS1CMA1 | |
| SCHEMBL10057884 | 0.80 | CMA1 (0.57) | ACEF2PRSS1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012017391-A2 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | CADILA PHARMACEUTICALS LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |