Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116895 | 0.82 | ATM (0.44) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL29705471 | 0.82 | ATM (0.44) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL10025490 | 0.79 | ITGB1 (0.36) | ATMTDP1ALDH1A1HIF1ACASP6 | |
| SCHEMBL6583252 | 0.76 | CYP1A2 (0.45) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL31558555 | 0.76 | CYP1A2 (0.45) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL18681415 | 0.75 | TDP1 (0.44) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL27215211 | 0.75 | TDP1 (0.44) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL29361654 | 0.73 | TDP1 (0.54) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL57498 | 0.73 | TDP1 (0.54) | ATMTDP1ALDH1A1HIF1AVCAM1 | |
| SCHEMBL2975400 | 0.73 | ATM (0.40) | ATMTDP1ALDH1A1HIF1AVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207173-B2 | Benzimidazoles and analogs thereof as antivirals | ISIS PHARMACEUTICALS, INC. (US) | 2012-06-26 | — | — | US | disclosed |