Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30755485 | 0.92 | CFTR (0.43) | CFTRBACE1CISD2AKR1C3AKR1C2 | |
| SCHEMBL10058710 | 0.88 | NOTUM (0.51) | CFTRBACE1CISD2AKR1C3AKR1C2 | |
| SCHEMBL27372936 | 0.86 | EGFR (0.52) | CFTRBACE1CISD2AKR1C3AKR1C2 | |
| SCHEMBL30755251 | 0.86 | EGFR (0.52) | CFTRBACE1CISD2AKR1C3AKR1C2 | |
| SCHEMBL6698582 | 0.82 | CFTR (0.55) | CFTRBACE1AKR1C3AKR1C2PTPN1 | |
| SCHEMBL30755410 | 0.79 | BACE1 (0.44) | CFTRBACE1CISD2PTPN1MAPT | |
| SCHEMBL7041867 | 0.79 | BACE1 (0.44) | CFTRBACE1CISD2PTPN1MAPT | |
| SCHEMBL5937194 | 0.79 | CYP46A1 (0.68) | CFTRBACE1AKR1C3AKR1C2PTPN1 | |
| SCHEMBL23354519 | 0.77 | CFTR (0.63) | CFTRBACE1AKR1C3AKR1C2PTPN1 | |
| SCHEMBL2267996 | 0.77 | SLC2A1 (0.51) | AKR1C3AKR1C2PTPN1KDM1ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114993-B2 | Use of aryl chlorides in palladium-catalyzed C-H bond functionalization | THE UNIVERSITY OF HOUSTON SYSTEM (US) | 2012-02-14 | — | — | US | disclosed |
| US-20090012293-A1 | USE OF ARYL CHLORIDES IN PALLADIUM-CATALYZED C-H BOND FUNCTIONALIZATION | THE UNIVERSITY OF HOUSTON SYSTEM (US) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012293-A1 | USE OF ARYL CHLORIDES IN PALLADIUM-CATALYZED C-H BOND FUNCTIONALIZATION | DBH, DDT, CYCS | CFTR 2800/4885BACE1 4452/4885CISD2 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.