Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.44 |
| ▸ | NAALAD2 | Q9Y3Q0 | 8/20 | 0.44 |
| ▸ | TSG101 | Q99816 | 4/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11952927 | 1.00 | PRMT5 (0.44) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL13747486 | 0.94 | PRMT5 (0.46) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL10060515 | 0.94 | PRMT5 (0.46) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL14262326 | 0.94 | PRMT5 (0.46) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL13164737 | 0.89 | PRMT5 (0.42) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL13203414 | 0.87 | PRMT5 (0.46) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL12651696 | 0.84 | TSG101 (0.38) | PRMT5WDR77TSG101 | |
| SCHEMBL18754963 | 0.79 | XIAP (0.35) | PRMT5WDR77NAALAD2TSG101NR1H2 | |
| SCHEMBL14271924 | 0.76 | NAALAD2 (0.50) | PRMT5WDR77NAALAD2TSG101FOLH1 | |
| SCHEMBL13754061 | 0.76 | NAALAD2 (0.52) | PRMT5WDR77NAALAD2TSG101FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163792-B2 | IAP BIR domain binding compounds | PHARMASCIENCE INC. (CA) | 2012-04-24 | — | — | US | disclosed |
| US-20090192140-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS INC. (CA) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192140-A1 | IAP BIR DOMAIN BINDING COMPOUNDS | BIRC5, BIRC2, BIRC3 | PRMT5 2094/4885WDR77 588/4885NAALAD2 1469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.