Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | JUN | P05412 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11928814 | 0.80 | HDAC1 (0.68) | HDAC1HDAC2HDAC8GSK3BNFKB1 | |
| SCHEMBL11928824 | 0.80 | HDAC1 (0.68) | HDAC1HDAC2HDAC8GSK3BNFKB1 | |
| SCHEMBL29126022 | 0.79 | ALDH1A1 (0.50) | PSMB5GRIK1GRIK2KDM4EALDH1A1 | |
| SCHEMBL1566212 | 0.78 | PSMB5 (0.61) | HDAC1HDAC2HDAC8PSMB5GSK3B | |
| SCHEMBL10061392 | 0.78 | FGFR1 (0.44) | PSMB5TOP2AALDH1A1HPGD | |
| SCHEMBL10061370 | 0.77 | GSK3B (0.50) | HDAC1HDAC2HDAC8GSK3BJUN | |
| SCHEMBL9972320 | 0.77 | HDAC1 (0.67) | HDAC1HDAC2HDAC8GSK3BNFKB1 | |
| SCHEMBL13358184 | 0.77 | HDAC1 (0.67) | HDAC1HDAC2HDAC8GSK3BNFKB1 | |
| SCHEMBL24433950 | 0.77 | HDAC1 (0.67) | HDAC1HDAC2HDAC8PSMB5GSK3B | |
| SCHEMBL18958893 | 0.76 | HDAC1 (0.53) | HDAC1HDAC2HDAC8PSMB5GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | L1CAM, LY96, GMFG | HDAC1 1136/4885HDAC2 1389/4885HDAC8 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.