Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC1R | Q01726 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730868 | 0.89 | ACHE (0.49) | CYP2D6LMNAHTTKMT2AACHE | |
| SCHEMBL15492796 | 0.85 | HTT (0.55) | LMNAHTTKMT2AACHECA2 | |
| SCHEMBL5767768 | 0.84 | SLC6A2 (0.58) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL10433983 | 0.84 | KMT2A (0.57) | LMNAHTTKMT2AACHE | |
| SCHEMBL14194596 | 0.83 | PRKCZ (0.51) | SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL10433976 | 0.83 | KMT2A (0.56) | LMNAHTTKMT2A | |
| SCHEMBL8821304 | 0.78 | TACR1 (0.50) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL14044360 | 0.78 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3LMNAHTT | |
| SCHEMBL70402 | 0.78 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3LMNAHTT | |
| SCHEMBL2779198 | 0.78 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268631-A1 | AMINOPIPERIDINYL DERIVATIVES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009118254-A1 | AMINOPIPERIDINYL DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-01 | — | — | WO | disclosed |