Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.64 |
| ▸ | PRKACA | P17612 | 3/20 | 0.64 |
| ▸ | PRKX | P51817 | 3/20 | 0.64 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.64 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.64 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.64 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.64 |
| ▸ | GPR142 | Q7Z601 | 13/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.50 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15116260 | 1.00 | ROCK2 (0.64) | ROCK2ROCK1PRKACAPRKXPRKG1 | |
| SCHEMBL10063170 | 0.80 | POLB (0.51) | GPR142AURKBAURKATTKITK | |
| SCHEMBL15116264 | 0.80 | POLB (0.51) | GPR142AURKBAURKATTKITK | |
| SCHEMBL10063122 | 0.80 | ROCK2 (0.59) | ROCK2ROCK1PRKACAPRKXPRKG1 | |
| SCHEMBL3102214 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKXPRKG1 | |
| SCHEMBL3092785 | 0.78 | ROCK1 (1.00) | ROCK2ROCK1PRKACAPRKXPRKG1 | |
| SCHEMBL3104425 | 0.78 | ROCK1 (1.00) | ROCK2ROCK1PRKACAPRKXPRKG1 | |
| SCHEMBL10063108 | 0.78 | GPR142 (0.57) | ROCK2ROCK1MAPK1GPR142AURKB | |
| SCHEMBL10063136 | 0.76 | MCL1 (0.57) | ROCK2ROCK1GPR142AURKBAURKA | |
| SCHEMBL15850171 | 0.76 | ITK (0.67) | GPR142AURKBAURKATTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338597-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338597-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-25 | — | — | US | disclosed |
| US-20120190699-A1 | PYRIDONES USEFUL AS INHIBITORS OF KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190699-A1 | PYRIDONES USEFUL AS INHIBITORS OF KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-26 | — | — | US | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190699-A1 | PYRIDONES USEFUL AS INHIBITORS OF KINASES | MAP3K20, MAP3K6, MAP3K5 | ROCK2 442/4885ROCK1 441/4885PRKACA 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.