Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.89 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.66 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15202958 | 0.94 | KCNH2 (1.00) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL15202998 | 0.92 | KCNH2 (0.89) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL10063163 | 0.86 | KCNH2 (0.68) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL10063524 | 0.85 | KCNH2 (0.67) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL13243464 | 0.83 | KCNH2 (0.69) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL2988260 | 0.83 | KCNH2 (0.69) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL13243461 | 0.83 | KCNH2 (0.69) | KCNH2CHRM4CHRM1OPRM1OPRL1 | |
| SCHEMBL7290423 | 0.82 | KCNH2 (0.63) | KCNH2L3MBTL1 | |
| SCHEMBL12791450 | 0.80 | HSD11B1 (0.63) | KCNH2CHRM4OPRM1OPRL1OPRK1 | |
| SCHEMBL1859950 | 0.80 | OPRM1 (1.00) | KCNH2OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020813-A1 | FUSED-RING PYRROLIDINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2012-02-16 | — | — | WO | disclosed |