Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19265679 | 0.85 | ALDH1A1 (0.62) | ALDH1A1RECQLTSHRMAPTHDAC6 | |
| SCHEMBL8290247 | 0.82 | ALDH1A1 (0.43) | ALDH1A1RECQLTSHRNPC1RAB9A | |
| SCHEMBL21200181 | 0.81 | NPC1 (0.73) | ALDH1A1RECQLTSHRMAPTHDAC6 | |
| SCHEMBL14050118 | 0.81 | MAPT (0.76) | ALDH1A1RECQLTSHRMAPTHDAC6 | |
| SCHEMBL3640134 | 0.80 | LMNA (0.64) | ALDH1A1TSHRMAPTHDAC6NPC1 | |
| SCHEMBL17050825 | 0.79 | ALDH1A1 (0.74) | ALDH1A1RECQLTSHRMAPTHDAC6 | |
| Iodide SCHEMBL3451153 | 0.78 | LMNA (0.62) | ALDH1A1TSHRMAPTHDAC6NPC1 | |
| SCHEMBL4728786 | 0.78 | HDAC6 (0.67) | ALDH1A1RECQLTSHRMAPTHDAC6 | |
| SCHEMBL17933573 | 0.78 | MAPT (0.62) | ALDH1A1RECQLTSHRMAPTHDAC6 | |
| Iodide SCHEMBL3451154 | 0.78 | LMNA (0.62) | ALDH1A1TSHRMAPTHDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028975-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND ANALOGS THEREOF | SCHERING CORPORATION | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028975-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND ANALOGS THEREOF | PDE2A, PDE5A, PDE4A | ALDH1A1 718/4885RECQL 881/4885TSHR 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.