SCHEMBL1006449

SCHEMBL1006449

NC(=O)c1cc(Br)cc(Br)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 6/20 0.60
TSHR P16473 3/20 0.44
HTT P42858 2/20 0.44
APOBEC3A P31941 1/20 0.44
APOBEC3G Q9HC16 1/20 0.44
CYP3A4 P08684 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
POLB P06746 3/20 0.42
MAPT P10636 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
NCOA1 Q15788 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
CYP2C19 P33261 1/20 0.42
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42
PMP22 Q01453 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
DGAT1 O75907 1/20 0.40
ALDH1A1 P00352 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1824174 0.94 PARP1 (0.60) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL25159913 0.85 PARP1 (0.52) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL15484864 0.85 PARP1 (0.52) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL1363884 0.84 PARP1 (0.50) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL12607365 0.84 PARP1 (0.50) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL31222695 0.84 PARP1 (0.50) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL1363329 0.84 PARP1 (0.50) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL5223135 0.84 PARP1 (0.50) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL553127 0.80 PARP1 (0.47) PARP1TSHRHTTAPOBEC3AAPOBEC3G
SCHEMBL25432683 0.79 PARP1 (0.55) PARP1TSHRHTTAPOBEC3AAPOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117110458-A Method for detecting halogenated benzamide by solid phase extraction-liquid chromatography tandem mass spectrometry 浙江工业大学 2023-11-24 CN claimed
CN-105363394-B A kind of preparation and application of the magnetic fluorescence molecular engram nanoparticle for detecting nitrobenzene 济南大学 2017-11-07 CN claimed
EP-1377589-B1 OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2005-09-07 EP claimed
US-20040224992-A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2004-11-11 US claimed
WO-2004075864-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2004-09-10 WO claimed
CN-117110458-B Method for detecting halogenated benzamide by solid phase extraction-liquid chromatography tandem mass spectrometry 浙江工业大学 2025-10-31 CN disclosed
US-20250319056-A1 METHODS FOR TREATING CANCER UNIV INDIANA TRUSTEES (US) 2025-10-16 US disclosed
CN-117110458-A Method for detecting halogenated benzamide by solid phase extraction-liquid chromatography tandem mass spectrometry 浙江工业大学 2023-11-24 CN disclosed
CN-117110458-A Method for detecting halogenated benzamide by solid phase extraction-liquid chromatography tandem mass spectrometry 浙江工业大学 2023-11-24 CN disclosed
CN-105363394-B A kind of preparation and application of the magnetic fluorescence molecular engram nanoparticle for detecting nitrobenzene 济南大学 2017-11-07 CN disclosed
US-8778219-B2 Ionic liquids for separation of olefin-paraffin mixtures UT-BATTELLE, LLC (US) 2014-07-15 US disclosed
US-20130338389-A1 IONIC LIQUIDS FOR SEPARATION OF OLEFIN-PARAFFIN MIXTURES UT-BATTELLE, LLC (US) 2013-12-19 US disclosed
US-20080031884-A1 COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES BAUSCH HEALTH US, LLC 2008-02-07 US disclosed
WO-2008008059-A1 ANTI-CANCER AGENTS ANS USES THEREOF LOCUS PHARMACEUTICALS, INC. (US) 2008-01-17 WO disclosed
US-20080009437-A1 Pharmaceutical Compositions and Method for Treating Dry Eye SALIX PHARMACEUTICALS, INC. 2008-01-10 US disclosed
WO-2008005686-A2 COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE BAUSCH & LOMB INCORPORATED (US) 2008-01-10 WO disclosed
US-20060270686-A1 Anti-cancer agents and uses thereof LOCUS PHARMACEUTICALS, INC. 2006-11-30 US disclosed
US-20040224992-A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2004-11-11 US disclosed
WO-2004075864-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2004-09-10 WO disclosed
US-4147725-A Process for preparing aniline compounds from amides with rhodium THE DOW CHEMICAL COMPANY (US) 1979-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130338389-A1 IONIC LIQUIDS FOR SEPARATION OF OLEFIN-PARAFFIN MIXTURES POU2F1, POU2F2, POF1B PARP1 4538/4885TSHR 4283/4885HTT 3924/4885
US-20080031884-A1 COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES PTGIR, GCGR, NR3C1 PARP1 3365/4885TSHR 375/4885HTT 3695/4885
US-20080009437-A1 Pharmaceutical Compositions and Method for Treating Dry Eye NR3C1, GCGR, GPBAR1 PARP1 3952/4885TSHR 78/4885HTT 4296/4885
US-20060270686-A1 Anti-cancer agents and uses thereof H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, MCL1, CBR3 PARP1 3014/4885TSHR 2744/4885HTT 3953/4885
US-20250319056-A1 METHODS FOR TREATING CANCER HSP90AB1, HSP90B1, HSP90AB2P PARP1 908/4885TSHR 4794/4885HTT 438/4885
US-20040224992-A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof NR3C1, NR3C2, MC2R PARP1 3405/4885TSHR 586/4885HTT 2423/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.