SCHEMBL1006493

SCHEMBL1006493

NC(=O)c1ccccc1C1CCNCC1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
IKBKB O14920 1/20 0.53
CHUK O15111 1/20 0.53
PARP1 P09874 8/20 0.52
HTR2C P28335 7/20 0.51
SIRT2 Q8IXJ6 1/20 0.50
PARP2 Q9UGN5 2/20 0.46
ADRA1A P35348 1/20 0.46
HTR1A P08908 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A4 P31645 1/20 0.45
SLC6A3 Q01959 1/20 0.45
CDC7 O00311 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28243995 0.98 HTR2C (0.53) IKBKBCHUKPARP1HTR2CSIRT2
SCHEMBL30554038 0.94 PARP1 (0.56) IKBKBCHUKPARP1HTR2CSIRT2
SCHEMBL5330092 0.90 PARP1 (0.54) IKBKBCHUKPARP1SIRT2ADRA1A
SCHEMBL14869717 0.90 PARP1 (0.54) IKBKBCHUKPARP1SIRT2ADRA1A
SCHEMBL5968190 0.90 PARP1 (0.54) IKBKBCHUKPARP1SIRT2ADRA1A
Hydrochloric Acid SCHEMBL3669412 0.89 PARP1 (0.53) IKBKBCHUKPARP1SIRT2ADRA1A
Hydrochloric Acid SCHEMBL28155968 0.89 PARP1 (0.53) IKBKBCHUKPARP1SIRT2ADRA1A
Hydrochloric Acid SCHEMBL28155977 0.89 PARP1 (0.53) IKBKBCHUKPARP1SIRT2ADRA1A
SCHEMBL161548 0.87 ADRA1A (0.51) IKBKBCHUKSIRT2ADRA1A
SCHEMBL28212021 0.87 ADRA1A (0.51) IKBKBCHUKSIRT2ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4274825-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2023-11-15 EP claimed
WO-2022150381-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2022-07-14 WO claimed
EP-3898629-A1 IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS F. Hoffmann-La Roche AG (CH) 2021-10-27 EP claimed
WO-2020127075-A1 IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS F. HOFFMANN-LA ROCHE AG (CH) 2020-06-25 WO claimed
CN-106824946-A A kind of high-pressure cleaning device and its method of work for carbon tetrachloride processing pond 徐州工程学院 2017-06-13 CN claimed
WO-2009067547-A1 POLO-LIKE KINASE INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-05-28 WO claimed
EP-1831183-A1 1,6-SUBSTITUTED (3R,6R)-3-(2,3-DIHYDRO-1H-INDEN-2-YL)-2,5-PIPERAZINEDIONE DERIVATIVES AS OXYTOCIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PRE-TERM LABOUR, DYSMENORRHEA AND ENDOMETRIOSIS GLAXO GROUP LIMITED (GB) 2007-09-12 EP claimed
WO-2006067462-A1 1,6 - SUBSTITUTED (3R,6R) -3- (2,3-DIHYDRO-1H-INDEN-2-YL)-2,5-PIPERAZINEDIONE DERIVATIVES AS OXYTOCIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PRE-TERM LABOUR, DYSMENORRHEA AND ENDOMETRIOSIS GLAXO GROUP LIMITED (GB) 2006-06-29 WO claimed
CN-1729180-A Piperazinyl and diazapanyl benzamides and benzthioamides JANSSEN PHARMACEUTICA NV (BE) 2006-02-01 CN claimed
EP-4305022-A1 ANTI-VIRAL COMPOUNDS Infex Therapeutics Limited (GB) 2024-01-17 EP disclosed
EP-4274825-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2023-11-15 EP disclosed
WO-2022189810-A1 ANTI-VIRAL COMPOUNDS Infex Therapeutics Limited (GB) 2022-09-15 WO disclosed
WO-2022150381-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2022-07-14 WO disclosed
CN-107847765-A The piperidine derivative of 1,4 substitutions 赛福伦公司 2018-03-27 CN disclosed
CN-1871238-A Triaza-spiropiperidine derivatives for use as GLYT-1 inhibitors in the treatment of neurological and neuropsychiatric disorders HOFFMANN LA ROCHE (CH) 2006-11-29 CN disclosed
WO-2006044687-A2 KINASE INHIBITORS TAKEDA SAN DIEGO, INC. (US) 2006-04-27 WO disclosed
CN-1729180-A Piperazinyl and diazapanyl benzamides and benzthioamides JANSSEN PHARMACEUTICA NV (BE) 2006-02-01 CN disclosed
CN-1602196-A Ureas of 2-aminobenzothiazoles as adenosine modulators HOFFMANN LA ROCHE (CH) 2005-03-30 CN disclosed
CN-1468227-A Non-imidazole aryloxyalkylamines ����-������ҩƷ��˾ 2004-01-14 CN disclosed
CN-1303372-A New heterocyclically substituted amides, their production and their use BASF AG (DE) 2001-07-11 CN disclosed