Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005697 | 0.85 | NOD2 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10065051 | 0.82 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10064904 | 0.78 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2343252 | 0.77 | HTR6 (0.50) | TP53KMT2ANOD2NOD1PTGDR | |
| SCHEMBL2731882 | 0.76 | HTR6 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2344679 | 0.76 | NOD2 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10064902 | 0.75 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2540534 | 0.73 | NOD2 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2345728 | 0.73 | NOD2 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2346812 | 0.73 | NOD2 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059568-A1 | NOVEL WATER-SOLUBLE INDOLOBENZAZEPINE MOLECULES DEMONSTRATING ANTIMITOTIC, ANTIVASCULAR, AND ANTITUMOR ACTIVITIES IN VIVO | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-05-10 | — | — | WO | disclosed |