Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.76 |
| ▸ | SCD | O00767 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 7/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30370064 | 0.86 | LRRK2 (1.00) | LRRK2SCDRAB9ANPC1MAPT | |
| SCHEMBL29947467 | 0.86 | SCD (0.72) | LRRK2SCDRAB9ANPC1MAPT | |
| SCHEMBL24729555 | 0.86 | SCD (0.72) | LRRK2SCDRAB9ANPC1MAPT | |
| SCHEMBL2190910 | 0.86 | SCD (0.72) | LRRK2SCDRAB9ANPC1MAPT | |
| SCHEMBL4921088 | 0.84 | SCD (1.00) | SCDRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL4912981 | 0.83 | SCD (1.00) | SCDRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL2190163 | 0.82 | RAB9A (0.76) | SCDRAB9ANPC1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL16554234 | 0.82 | SCD (0.98) | SCDRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL19270375 | 0.80 | SCD (0.67) | SCDRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL19253769 | 0.80 | SCD (0.63) | LRRK2SCDRAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153803-B2 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090259044-A1 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2009-10-15 | — | — | US | disclosed |
| US-20090069559-A1 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069559-A1 | Compositions and methods for modulating sirtuin activity | SIRT2, SIRT1, SIRT3 | LRRK2 110/4885SCD 684/4885RAB9A 1158/4885 |
| US-20090259044-A1 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | SIRT2, SIRT1, SIRT3 | LRRK2 110/4885SCD 684/4885RAB9A 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.