Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6427012 | 0.81 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6382528 | 0.77 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6381208 | 0.69 | KMT2A (0.39) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1007963 | 0.67 | LMNA (0.33) | — | |
| SCHEMBL31158519 | 0.66 | MAPK1 (0.39) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6381885 | 0.64 | HTT (0.39) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6383925 | 0.64 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29777572 | 0.64 | KDM4E (0.35) | ALDH1A1 | |
| SCHEMBL6381321 | 0.63 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1007598 | 0.62 | SMN1; SMN2 (0.35) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2269990-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | GRIN1, GRM1, GRIK1 | ALDH1A1 614/4885SMN1; SMN2 3616/4885HPGD 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.