Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 8/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060106 | 0.87 | IDH1 (0.31) | IRAK4IDH1 | |
| SCHEMBL10067630 | 0.87 | TRPV3 (0.31) | IDH1 | |
| SCHEMBL10067629 | 0.87 | TRPV3 (0.31) | IDH1 | |
| SCHEMBL10067942 | 0.86 | IDH1 (0.31) | IDH1 | |
| SCHEMBL13060037 | 0.85 | — | — | |
| SCHEMBL2633646 | 0.85 | — | — | |
| SCHEMBL2633775 | 0.84 | MAPK1 (0.34) | MAPK1 | |
| SCHEMBL13059455 | 0.83 | BTK (0.35) | IRAK4IDH1 | |
| SCHEMBL13060039 | 0.82 | ULK1 (0.32) | HTRA1IDO1 | |
| SCHEMBL10068280 | 0.81 | JAK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163917-B2 | Azaindoles useful as inhibitors of Janus kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |