Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.50 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23041356 | 0.84 | FABP6 (0.43) | FABP6ATMMEN1MAPTKMT2A | |
| SCHEMBL15825576 | 0.77 | AMY1A (0.33) | FABP6ATMMEN1MAPTKMT2A | |
| SCHEMBL30038044 | 0.77 | FABP6 (0.63) | FABP6ATMMEN1MAPTKMT2A | |
| SCHEMBL1170803 | 0.77 | FABP6 (0.63) | FABP6ATMMEN1MAPTKMT2A | |
| SCHEMBL1038167 | 0.77 | FABP6 (0.63) | FABP6ATMMEN1MAPTKMT2A | |
| SCHEMBL9305169 | 0.75 | KMT2A (0.58) | MAPTKMT2AKDM4EMETAP1METAP2 | |
| SCHEMBL9305161 | 0.75 | KMT2A (0.44) | MEN1MAPTKMT2AMETAP1METAP2 | |
| SCHEMBL441602 | 0.74 | GAA (0.53) | MEN1KMT2AHRH4NPC1RAB9A | |
| SCHEMBL30860105 | 0.74 | GAA (0.53) | MEN1KMT2AHRH4NPC1RAB9A | |
| SCHEMBL1192746 | 0.74 | FABP6 (0.59) | FABP6ATMMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021038419-A1 | KINASE INHIBITORS AND METHODS OF SYNTHESIS AND TREATMENT | INSILICO MEDICINE IP LIMITED (CN) | 2021-03-04 | — | — | WO | disclosed |
| EP-2935244-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS KINASE INHIBITORS | SELVITA S A (PL) | 2018-06-27 | — | — | EP | disclosed |
| EP-2268620-A2 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF- KAPPA B ACTIVATION | Burnham Institute for Medical Research (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009120874-A2 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-кB ACTIVATION | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-10-01 | — | — | WO | disclosed |
| WO-2009120874-A2 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-кB ACTIVATION | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247520-A1 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247520-A1 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247520-A1 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247520-A1 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION | NFKBIA, IKBKB, NFRKB | FABP6 1659/4885ATM 2286/4885MEN1 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.