Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068226 | 1.00 | HRH2 (0.42) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL15206685 | 1.00 | HRH2 (0.42) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL524818 | 1.00 | HRH2 (0.42) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL15206684 | 1.00 | HRH2 (0.42) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL525678 | 1.00 | HRH2 (0.42) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL15221568 | 0.86 | HTR2A (0.43) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL8170396 | 0.86 | HTR2A (0.51) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL8164477 | 0.86 | HTR2A (0.51) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL15206688 | 0.84 | HTR2A (0.46) | HRH2HTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL15206971 | 0.84 | HTR2A (0.46) | HRH2HTR2AHTR2CHRH1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598496-B1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LESVI LABORATORIOS SL (ES) | 2014-03-19 | — | — | EP | claimed |
| US-8653280-B2 | Process for the preparation of asenapine | Laboratories Lesvi, S.L. (ES) | 2014-02-18 | — | — | US | claimed |
| US-20130225835-A1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LABORATORIOS LESVI, S.L. (ES) | 2013-08-29 | — | — | US | claimed |
| EP-2598496-B1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LESVI LABORATORIOS SL (ES) | 2014-03-19 | — | — | EP | disclosed |
| EP-2598496-B1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LESVI LABORATORIOS SL (ES) | 2014-03-19 | — | — | EP | disclosed |
| US-8653280-B2 | Process for the preparation of asenapine | Laboratories Lesvi, S.L. (ES) | 2014-02-18 | — | — | US | disclosed |
| US-8653280-B2 | Process for the preparation of asenapine | Laboratories Lesvi, S.L. (ES) | 2014-02-18 | — | — | US | disclosed |
| US-8653280-B2 | Process for the preparation of asenapine | Laboratories Lesvi, S.L. (ES) | 2014-02-18 | — | — | US | disclosed |
| US-20130225835-A1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LABORATORIOS LESVI, S.L. (ES) | 2013-08-29 | — | — | US | disclosed |
| US-20130225835-A1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LABORATORIOS LESVI, S.L. (ES) | 2013-08-29 | — | — | US | disclosed |
| US-20130225835-A1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LABORATORIOS LESVI, S.L. (ES) | 2013-08-29 | — | — | US | disclosed |
| WO-2012013766-A1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | LABORATORIOS LESVI, S.L. (ES) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225835-A1 | NOVEL PROCESS FOR THE PREPARATION OF ASENAPINE | CYP3A5, ADRB1, ADRA1B | HRH2 1500/4885HTR2A 489/4885HTR2C 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.