Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | STAT3 | P40763 | 2/20 | 0.53 |
| ▸ | USP1 | O94782 | 1/20 | 0.47 |
| ▸ | USP19 | O94966 | 1/20 | 0.47 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068413 | 0.89 | STAT3 (0.51) | ALDH1A1STAT3USP1USP19WDR48 | |
| SCHEMBL10037446 | 0.81 | STAT3 (0.60) | ALDH1A1STAT3KDM4EPOLBMEN1 | |
| SCHEMBL28705 | 0.73 | STAT3 (0.56) | ALDH1A1STAT3USP1USP19WDR48 | |
| SCHEMBL6577994 | 0.73 | STAT3 (0.61) | ALDH1A1STAT3KDM4EPOLBMEN1 | |
| SCHEMBL16167166 | 0.73 | STAT3 (0.56) | ALDH1A1STAT3USP1USP19WDR48 | |
| SCHEMBL12640087 | 0.73 | STAT3 (0.75) | ALDH1A1STAT3KDM4EPOLBMEN1 | |
| Flavone SCHEMBL27994354 | 0.73 | TNKS (0.84) | KDM4EPOLBSMN1; SMN2NPC1RAB9A | |
| Anthraquinone SCHEMBL27901882 | 0.73 | MEN1 (0.67) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| Anthraquinone SCHEMBL27283959 | 0.72 | MEN1 (0.75) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL19669614 | 0.72 | STAT3 (0.59) | ALDH1A1STAT3USP1USP19WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | TAHEEBO JAPAN CO., LTD. (JP) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | NR2C2, NR0B2, NR4A2 | ALDH1A1 862/4885STAT3 1855/4885USP1 3388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.