Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | CFB | P00751 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162593 | 0.89 | DRD2 (0.44) | SMN1; SMN2ALDH1A1CASP8GSK3BDYRK1A | |
| SCHEMBL27649798 | 0.86 | GSK3B (0.40) | SMN1; SMN2ALDH1A1CASP8GSK3BDYRK1A | |
| SCHEMBL10253093 | 0.84 | CASP8 (0.42) | ALDH1A1CASP8GSK3BDYRK1AL3MBTL1 | |
| SCHEMBL13162592 | 0.84 | EPHX2 (0.39) | SMN1; SMN2CASP8PLA2G4ABAZ2AL3MBTL1 | |
| SCHEMBL1041745 | 0.83 | CASP8 (0.38) | SMN1; SMN2ALDH1A1CASP8GSK3BDYRK1A | |
| SCHEMBL1141577 | 0.82 | CASP8 (0.49) | ALDH1A1CASP8L3MBTL1LDHAPTGER1 | |
| SCHEMBL24978623 | 0.81 | CASP8 (0.42) | ALDH1A1CASP8GSK3BDYRK1AL3MBTL1 | |
| SCHEMBL2952296 | 0.81 | CASP8 (0.42) | ALDH1A1CASP8L3MBTL1LDHA | |
| SCHEMBL2969047 | 0.81 | GSK3B (0.46) | ALDH1A1CASP8GSK3BDYRK1AL3MBTL1 | |
| SCHEMBL10037325 | 0.81 | CASP8 (0.40) | SMN1; SMN2ALDH1A1CASP8L3MBTL1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077711-A1 | Novel Ligands and Libraries of Ligands | SUNESIS PHARMACEUTICALS, INC. (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077711-A1 | Novel Ligands and Libraries of Ligands | LSS, ABCG2, SELL | SMN1; SMN2 4117/4885ALDH1A1 533/4885CASP8 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.