CASP8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL625722	0.84	20/20
SCHEMBL627324	0.71	20/20
SCHEMBL627211	0.69	20/20
SCHEMBL626093	0.68	20/20
SCHEMBL626915	0.60	20/20
SCHEMBL627392	0.50	20/20
SCHEMBL78538	0.53	19/20
SCHEMBL78539	0.53	19/20
SCHEMBL78540	0.53	19/20
SCHEMBL626605	0.51	19/20
SCHEMBL473150	0.56	18/20
SCHEMBL473151	0.56	18/20
SCHEMBL473152	0.55	18/20
SCHEMBL473241	0.54	18/20
SCHEMBL473242	0.54	18/20
SCHEMBL473170	0.53	17/20
SCHEMBL473171	0.53	17/20
SCHEMBL473172	0.53	17/20
SCHEMBL473272	0.48	17/20
SCHEMBL473273	0.48	17/20

Clinical trials — most relevant to CASP8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Sunitinib Malate in Treating Patients With Locally Recurrent, Locally Advanced, Unresectable, or Metastatic Urinary Tract Cancer	PHASE2	UNKNOWN
A Study of IDN-6556 in Subjects With Liver Cirrhosis	PHASE2	COMPLETED
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
18F-CP18 Imaging Studies for Cancer Treatment With Birinapant	PHASE2	WITHDRAWN
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients	PHASE1/PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan	nan	UNKNOWN
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients	nan	RECRUITING
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
The Effect of TRA-8 on Ovarian Cancer Tissue	nan	COMPLETED
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
The T Cell Activator of Cell Killing (TACK) IT ON STUDY	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CASP8 binder may also engage these)

Protein	Name	Similarity
Q9JHX4	—	0.987	Q9JHX4 →
O89110	—	0.975	O89110 →
P55215	—	0.966	P55215 →
CASP2	Caspase-2	0.965	landscape →
Q98943	—	0.965	Q98943 →
O35732	—	0.964	O35732 →
P29452	—	0.963	P29452 →
O15519	—	0.961	O15519 →
P29594	—	0.960	P29594 →
P43527	—	0.958	P43527 →
Q3T0P5	—	0.957	Q3T0P5 →
O75601	—	0.957	O75601 →
Q5RD56	—	0.955	Q5RD56 →
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.954	landscape →
Q9TV13	—	0.952	Q9TV13 →
Q2TBA3	—	0.952	Q2TBA3 →
CASP6	Caspase-6	0.952	landscape →
Q9UBK8	—	0.949	Q9UBK8 →
P70343	—	0.948	P70343 →
A0A1D5PPP7	—	0.948	A0A1D5PPP7 →
Q075B4	—	0.948	Q075B4 →
O35397	—	0.947	O35397 →
CASP1	Caspase-1	0.947	landscape →
Q153Z0	—	0.946	Q153Z0 →
Q5E9C1	—	0.946	Q5E9C1 →
CASP10	Caspase-10	0.945	landscape →
O08738	—	0.944	O08738 →
Q9MZV7	—	0.943	Q9MZV7 →
Q14CH1	—	0.941	Q14CH1 →
PARP4	Protein mono-ADP-ribosyltransferase PARP4	0.940	landscape →