Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007829 | 0.78 | ADORA2A (0.53) | TLR7TLR8ADORA2APOLBADRA1A | |
| SCHEMBL1061503 | 0.77 | TLR8 (0.55) | TLR7TLR8ADORA2AADORA3ADORA1 | |
| SCHEMBL1006095 | 0.73 | ADORA1 (0.49) | TLR7TLR8ADORA2ANUDT1ADORA3 | |
| SCHEMBL17054092 | 0.73 | GPBAR1 (0.53) | TLR8LMNAMCHR1GABRPGABRD | |
| SCHEMBL1010427 | 0.72 | TLR7 (0.57) | TLR7TLR8ADORA2ALMNAPOLB | |
| SCHEMBL1009385 | 0.72 | TLR7 (0.54) | TLR7TLR8ADORA2ALMNAPOLB | |
| SCHEMBL1703456 | 0.71 | TLR7 (0.57) | TLR7TLR8ADORA2ALMNAPOLB | |
| SCHEMBL1675410 | 0.71 | ADORA3 (0.43) | TLR7TLR8ADORA2AADORA3ADORA1 | |
| SCHEMBL1008185 | 0.70 | TLR7 (0.54) | TLR7TLR8ADORA2AADRA1ANUDT1 | |
| SCHEMBL1008581 | 0.69 | TLR7 (0.52) | TLR7TLR8ADORA2ANUDT1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268618-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2011-01-05 | — | — | EP | disclosed |