Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.57 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.45 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008185 | 0.77 | TLR7 (0.54) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1008808 | 0.77 | ADORA3 (0.51) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1703456 | 0.76 | TLR7 (0.57) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1062779 | 0.74 | ADORA3 (0.50) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL12733228 | 0.74 | ADORA3 (0.49) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1058579 | 0.74 | ADORA3 (0.49) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1007829 | 0.73 | ADORA2A (0.53) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1675691 | 0.73 | NCF1 (0.49) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1009385 | 0.73 | TLR7 (0.54) | TLR7TLR8ADORA2AADRA1AKCNH2 | |
| SCHEMBL1527890 | 0.73 | TLR7 (1.00) | TLR7TLR8ADORA2AADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268618-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2011-01-05 | — | — | EP | disclosed |