Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104894 | 1.00 | METAP1 (0.52) | METAP1SIGMAR1ADH1BADH1CADH1A | |
| SCHEMBL2265272 | 0.78 | ADH1B (0.40) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL9384810 | 0.78 | ADH1B (0.40) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL7418543 | 0.78 | ADH1B (0.40) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL23647071 | 0.76 | METAP1 (0.44) | METAP1SIGMAR1ADH1BADH1CADH1A | |
| SCHEMBL21516565 | 0.76 | ADH1B (0.37) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL7378214 | 0.76 | ADH1B (0.37) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL18526419 | 0.75 | METAP1 (0.47) | METAP1SIGMAR1ADH1BADH1CADH1A | |
| SCHEMBL9668100 | 0.75 | METAP1 (0.43) | METAP1SIGMAR1ADH1BADH1CADH1A | |
| SCHEMBL2748135 | 0.75 | METAP1 (0.55) | METAP1SIGMAR1CYP1A2METAP2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021876-A2 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012021874-A1 | PEPTIDOMIMETIC MACROCYCLES WITH THIOETHER LINKERS | AILERON THERAPEUTICS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |