Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | JAK2 | O60674 | 2/20 | 0.62 |
| ▸ | TYK2 | P29597 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | F2R | P25116 | 4/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069451 | 0.82 | KMT2A (0.79) | KMT2AMEN1NPC1RAB9AF2R | |
| SCHEMBL10069464 | 0.81 | F2R (0.70) | KMT2AF2RSMN1; SMN2 | |
| SCHEMBL10069453 | 0.80 | F2R (0.71) | JAK2TYK2F2RSMN1; SMN2 | |
| SCHEMBL24150224 | 0.78 | JAK2 (0.60) | KMT2AMEN1JAK2TYK2NPC1 | |
| SCHEMBL29899082 | 0.78 | NPC1 (0.61) | KMT2AMEN1JAK2TYK2ATM | |
| SCHEMBL16620629 | 0.78 | NPC1 (0.61) | KMT2AMEN1JAK2TYK2ATM | |
| SCHEMBL3514581 | 0.77 | TYK2 (1.00) | JAK2TYK2 | |
| SCHEMBL27615981 | 0.77 | KCNK9 (0.69) | KMT2AMEN1JAK2TYK2NPC1 | |
| SCHEMBL27473596 | 0.76 | MEN1 (0.69) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23070709 | 0.75 | KMT2A (0.68) | KMT2AMEN1NPC1RAB9AF2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |