Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16620629 | 1.00 | NPC1 (0.61) | NPC1RAB9AATMJAK2TYK2 | |
| SCHEMBL2783145 | 0.86 | NPC1 (0.68) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL23410523 | 0.85 | MAPK8 (0.62) | NPC1RAB9AGRM5MAPK8MAPK10 | |
| SCHEMBL29899004 | 0.85 | MAPK8 (0.62) | NPC1RAB9AGRM5MAPK8MAPK10 | |
| SCHEMBL29899009 | 0.84 | HTR1F (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29083781 | 0.84 | RAB9A (0.58) | NPC1RAB9AATMMEN1KMT2A | |
| SCHEMBL23410295 | 0.84 | HTR1F (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29083770 | 0.84 | IDE (0.58) | NPC1RAB9AATMGRM5MEN1 | |
| SCHEMBL16974225 | 0.84 | MEN1 (0.62) | NPC1RAB9AGRM5MEN1KMT2A | |
| SCHEMBL30565890 | 0.84 | MEN1 (0.62) | NPC1RAB9AGRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119562945-A | IKK inhibitors | 癌症研究技术有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-115151256-B | Novel compounds for the treatment of diseases associated with DUX4 expression | 因维戈疗法有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-115151257-B | Novel compounds for the treatment of diseases associated with DUX4 expression | 因维戈疗法有限公司 | 2024-07-12 | — | — | CN | disclosed |
| EP-4065107-A1 | NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION | Facio Intellectual Property B.V. (NL) | 2022-10-05 | — | — | EP | disclosed |
| CN-115151257-A | Novel compounds for the treatment of diseases associated with DUX expression | FACIO知识产权有限公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-115151256-A | Novel compounds for the treatment of diseases associated with DUX expression | FACIO知识产权有限公司 | 2022-10-04 | — | — | CN | disclosed |