Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882790 | 0.92 | KCNK9 (0.71) | KMT2AALDH1A1MEN1KCNK9SMN1; SMN2 | |
| SCHEMBL10069480 | 0.87 | KCNK9 (0.74) | KMT2AALDH1A1MEN1KCNK9SMN1; SMN2 | |
| SCHEMBL10069965 | 0.85 | KMT2A (1.00) | KMT2AALDH1A1MEN1SMN1; SMN2TP53 | |
| SCHEMBL13753200 | 0.84 | MTNR1B (0.75) | KMT2AALDH1A1MEN1SMN1; SMN2NPC1 | |
| SCHEMBL10969527 | 0.82 | KDM4E (0.72) | KMT2AALDH1A1MEN1SMN1; SMN2NPC1 | |
| SCHEMBL13753202 | 0.81 | L3MBTL1 (0.84) | KMT2AALDH1A1MEN1SMN1; SMN2NPC1 | |
| SCHEMBL30605275 | 0.80 | MTNR1B (0.73) | ALDH1A1SMN1; SMN2NPC1RAB9AMTNR1A | |
| SCHEMBL25938755 | 0.80 | MTNR1B (0.73) | ALDH1A1SMN1; SMN2NPC1RAB9AMTNR1A | |
| SCHEMBL10069470 | 0.80 | KCNK9 (0.81) | KMT2AALDH1A1MEN1KCNK9SMN1; SMN2 | |
| SCHEMBL12228183 | 0.80 | NPC1 (0.83) | KMT2AALDH1A1MEN1KCNK9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |