Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 13/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069474 | 0.87 | F2R (0.68) | F2RKMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL10069454 | 0.84 | F2R (0.72) | F2RKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL16722802 | 0.81 | NPSR1 (0.76) | KMT2ANPC1RAB9AALDH1A1NPSR1 | |
| SCHEMBL29168826 | 0.81 | RAB9A (0.73) | F2RKMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL30758595 | 0.81 | RAB9A (0.73) | F2RKMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL10069451 | 0.81 | KMT2A (0.79) | F2RKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL10069461 | 0.80 | F2R (1.00) | F2RKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL882810 | 0.80 | F2R (1.00) | F2RKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10069968 | 0.78 | RAB9A (0.71) | KMT2ANPC1RAB9AALDH1A1NPSR1 | |
| SCHEMBL882467 | 0.78 | F2R (1.00) | F2RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |