Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 0.67 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709195 | 0.90 | DRD4 (0.71) | DRD4SCN9A | |
| SCHEMBL10072407 | 0.88 | DRD4 (0.72) | DRD4 | |
| SCHEMBL1286816 | 0.86 | DRD4 (0.62) | DRD4SCN9A | |
| SCHEMBL1709219 | 0.83 | SCN9A (0.74) | DRD4SCN9A | |
| SCHEMBL18838471 | 0.83 | KCNH2 (0.56) | DRD4 | |
| SCHEMBL1709207 | 0.81 | SCN9A (0.54) | DRD4SCN9A | |
| SCHEMBL3163809 | 0.81 | DRD4 (1.00) | DRD4 | |
| SCHEMBL1286845 | 0.80 | SCN9A (0.66) | DRD4SCN9A | |
| SCHEMBL1709262 | 0.80 | SCN9A (0.52) | DRD4SCN9A | |
| SCHEMBL10072168 | 0.78 | SCN9A (0.56) | DRD4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |