Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 14/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071958 | 0.90 | DRD4 (0.67) | DRD4SCN9A | |
| SCHEMBL10072407 | 0.88 | DRD4 (0.72) | DRD4 | |
| SCHEMBL1286816 | 0.85 | DRD4 (0.62) | DRD4SCN9A | |
| SCHEMBL1709219 | 0.76 | SCN9A (0.74) | DRD4MEN1KMT2ASCN9A | |
| SCHEMBL1709207 | 0.74 | SCN9A (0.54) | DRD4KMT2ASCN9A | |
| SCHEMBL10072168 | 0.74 | SCN9A (0.56) | DRD4MEN1KMT2ASCN9A | |
| SCHEMBL1286815 | 0.73 | KMT2A (0.55) | DRD4KMT2ASCN9A | |
| SCHEMBL18838471 | 0.73 | KCNH2 (0.56) | DRD4MEN1KMT2ACHRM2CHRM3 | |
| SCHEMBL1709262 | 0.73 | SCN9A (0.52) | DRD4KMT2ASCN9A | |
| SCHEMBL1286845 | 0.73 | SCN9A (0.66) | DRD4KMT2ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |