Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 12/20 | 0.72 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286816 | 0.94 | DRD4 (0.62) | DRD4MCHR1 | |
| SCHEMBL1709195 | 0.88 | DRD4 (0.71) | DRD4 | |
| SCHEMBL10071958 | 0.88 | DRD4 (0.67) | DRD4 | |
| SCHEMBL1709209 | 0.81 | SMN1; SMN2 (0.53) | DRD4 | |
| SCHEMBL10072037 | 0.80 | SCN9A (0.62) | DRD4 | |
| SCHEMBL1709219 | 0.74 | SCN9A (0.74) | DRD4 | |
| SCHEMBL10072167 | 0.74 | SCN9A (0.61) | DRD4 | |
| SCHEMBL1709220 | 0.73 | SCN9A (0.55) | DRD4 | |
| SCHEMBL1709207 | 0.72 | SCN9A (0.54) | DRD4 | |
| SCHEMBL10072168 | 0.72 | SCN9A (0.56) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |