Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474708 | 0.89 | HSD11B1 (0.40) | HSD11B1OPRM1P2RX7ROCK2PARP1 | |
| SCHEMBL10072596 | 0.86 | HSD11B1 (0.41) | HSD11B1OPRM1CACNA1FCHRM1ADRA1D | |
| SCHEMBL12432122 | 0.86 | HSD11B1 (0.41) | HSD11B1OPRM1CACNA1FCHRM1ADRA1D | |
| SCHEMBL13955223 | 0.83 | HSD11B1 (0.39) | HSD11B1OPRM1CACNA1FCHRM1ADRA1D | |
| SCHEMBL13955044 | 0.81 | HSD11B1 (0.47) | HSD11B1OPRM1CACNA1FCHRM1ADRA1D | |
| SCHEMBL4510092 | 0.79 | HSD11B1 (0.38) | HSD11B1OPRM1OPRD1P2RX7 | |
| SCHEMBL13674528 | 0.79 | HSD11B1 (0.38) | HSD11B1OPRM1OPRD1P2RX7 | |
| SCHEMBL14365228 | 0.79 | HSD11B1 (0.39) | HSD11B1OPRM1OPRD1OPRK1P2RX7 | |
| SCHEMBL13674486 | 0.79 | P2RX7 (0.42) | HSD11B1P2RX7 | |
| SCHEMBL3001594 | 0.79 | P2RX7 (0.42) | HSD11B1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-B1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | disclosed |