Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | VDR | P11473 | 2/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.63 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.63 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.59 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14315480 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL17578641 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL17578745 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL330008 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL12644541 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL17898400 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL7992936 | 1.00 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL12644507 | 0.95 | USP2 (0.71) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL14570885 | 0.93 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA | |
| SCHEMBL5030971 | 0.93 | USP2 (0.79) | USP2MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008363-B2 | Preparation of bile acids and intermediates thereof | ALLERGAN SALES, LLC (US) | 2021-05-18 | — | — | US | disclosed |
| US-10889611-B2 | Sialyltransferase inhibitors and uses thereof | ACADEMIA SINICA (TW) | 2021-01-12 | — | — | US | disclosed |
| US-20200317716-A1 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF | ALLERGAN SALES, LLC (US) | 2020-10-08 | — | — | US | disclosed |
| EP-3002290-B1 | SYNTHESIS OF DEOXYCHOLIC ACID (DCA) | ALLERGAN SALES LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10633412-B2 | Preparation of bile acids and intermediates thereof | ALLERGAN SALES, LLC (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190048037-A1 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2019-02-14 | — | — | US | disclosed |
| WO-2017035501-A1 | SIALYLTRANSFERASE INHIBITORS AND USES THEREOF | ACADEMIA SINICA (TW) | 2017-03-02 | — | — | WO | disclosed |
| EP-3002290-A2 | SYNTHESIS OF DEOXYCHOLIC ACID (DCA) | Kythera Biopharmaceuticals, Inc. (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-2407475-B1 | synthetic bile acid preparation | KYTHERA BIOPHARMACEUTICALS INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2407475-A2 | Synthetic Bile Acid Composition, Method, and Preparation | Kythera Biopharmaceuticals, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| US-7902387-B2 | Preparation of bile acids and intermediates thereof | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-20100179337-A2 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2010-07-15 | — | — | US | disclosed |
| US-20090270642-A1 | Preparation of bile acids and intermediates thereof | KYTHERA BIOPHARMACEUTICALS, INC. | 2009-10-29 | — | — | US | disclosed |
| WO-2008157635-A2 | SYNTHETIC BILE ACID COMPOSITION, METHOD, AND PREPARATION | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179337-A2 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF | CYP7A1, CYP27A1, NR1H4 | USP2 2520/4885MAPT 3679/4885MEN1 2183/4885 |
| US-10889611-B2 | Sialyltransferase inhibitors and uses thereof | ST6GAL1, NEU1, GALNT1 | USP2 1906/4885MAPT 3133/4885MEN1 4085/4885 |
| US-11008363-B2 | Preparation of bile acids and intermediates thereof | CYP7A1, CYP27A1, NR1H4 | USP2 2520/4885MAPT 3679/4885MEN1 2183/4885 |
| US-20190048037-A1 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF | CYP7A1, CYP27A1, NR1H4 | USP2 2520/4885MAPT 3679/4885MEN1 2183/4885 |
| US-20200317716-A1 | PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF | CYP7A1, CYP27A1, NR1H4 | USP2 2520/4885MAPT 3679/4885MEN1 2183/4885 |
| US-10633412-B2 | Preparation of bile acids and intermediates thereof | CYP7A1, CYP27A1, NR1H4 | USP2 2520/4885MAPT 3679/4885MEN1 2183/4885 |
| US-20090270642-A1 | Preparation of bile acids and intermediates thereof | CYP7A1, CYP27A1, NR1H4 | USP2 2520/4885MAPT 3679/4885MEN1 2183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.