SCHEMBL10073748

SCHEMBL10073748

CNC(=O)c1ccc(CCC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(O)cc(C)nc34)c2Cl)cn1

nearest known ligand 0.65

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL659389 0.90 BDKRB2 (0.69) BDKRB2
SCHEMBL657029 0.89 BDKRB2 (0.63) BDKRB2
SCHEMBL660804 0.89 BDKRB2 (0.77) BDKRB2
SCHEMBL659601 0.88 BDKRB2 (0.62) BDKRB2
SCHEMBL656991 0.87 BDKRB2 (0.65) BDKRB2
SCHEMBL660715 0.87 BDKRB2 (0.58) BDKRB2
SCHEMBL10072959 0.86 BDKRB2 (0.57) BDKRB2
SCHEMBL10073317 0.85 BDKRB2 (0.60) BDKRB2
SCHEMBL657025 0.82 BDKRB2 (0.77) BDKRB2
SCHEMBL8364276 0.81 BDKRB2 (0.74) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012024419-A2 BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA ALCON RESEARCH, LTD. (US) 2012-02-23 WO disclosed