Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27519383 | 0.94 | HDAC4 (0.71) | HDAC1HDAC4KCNH2SMN1; SMN2LMNA | |
| SCHEMBL20828408 | 0.92 | HDAC1 (0.62) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL2787677 | 0.92 | HDAC1 (0.67) | HDAC1HDAC4KCNH2ALDH1A1KDM4E | |
| SCHEMBL65179 | 0.91 | HDAC6 (0.69) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL9610829 | 0.91 | ALDH1A1 (0.57) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL14217257 | 0.91 | HDAC1 (0.54) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL16356429 | 0.91 | HDAC6 (0.69) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL3013154 | 0.91 | ALDH1A1 (0.61) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL4424464 | 0.91 | ALDH1A1 (0.57) | HDAC1HDAC4KCNH2GAATHRB | |
| SCHEMBL2986364 | 0.90 | HRH3 (0.67) | HDAC1ALDH1A1KDM4EHIF1AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017222-A | Preparation method of imatinib impurity | QILU TIANHE PHARMACEUTICAL CO LTD | 2015-11-04 | — | — | CN | disclosed |
| US-20130203990-A1 | PROCESS FOR THE PREPARATION OF IMATINIB MESYLATE | DR. REDDY'S LABORATORIES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203990-A1 | PROCESS FOR THE PREPARATION OF IMATINIB MESYLATE | DR. REDDY'S LABORATORIES, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| WO-2012015999-A2 | PROCESS FOR THE PREPARATION OF IMATINIB MESYLATE | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203990-A1 | PROCESS FOR THE PREPARATION OF IMATINIB MESYLATE | ABL1, ABL2, PDGFRA | HDAC1 4679/4885HDAC4 4675/4885KCNH2 1872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.