Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 2/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 9/20 | 0.51 |
| ▸ | ROS1 | P08922 | 6/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602870 | 0.90 | GLO1 (0.62) | GLO1ALKMETEGFRLRRK2 | |
| SCHEMBL13084445 | 0.85 | ALK (0.58) | GLO1ALKMETEGFRROS1 | |
| SCHEMBL600864 | 0.83 | GLO1 (0.58) | GLO1ALKMETEGFRROS1 | |
| SCHEMBL600894 | 0.83 | GLO1 (0.56) | GLO1ALKMETEGFRROS1 | |
| SCHEMBL603073 | 0.82 | ALK (0.58) | GLO1ALKMETEGFRROS1 | |
| SCHEMBL1039383 | 0.81 | MAPK9 (0.66) | GLO1ALKMETEGFRROS1 | |
| SCHEMBL602346 | 0.81 | ULK1 (0.64) | GLO1ALKMETROS1 | |
| SCHEMBL1036294 | 0.80 | ALK (0.68) | GLO1ALKMETEGFRLRRK2 | |
| SCHEMBL624680 | 0.80 | ALK (0.55) | GLO1ALKMETEGFRROS1 | |
| SCHEMBL1459616 | 0.80 | EGFR (0.56) | GLO1ALKMETEGFRROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040955-A1 | FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS | CELLZOME LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20120040955-A1 | FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS | CELLZOME LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040955-A1 | FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS | JAK3, JAK2, JAK1 | GLO1 3765/4885ALK 1095/4885MET 3143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.