SCHEMBL10074698

SCHEMBL10074698

Cc1cc(-c2cnc3c(n2)-c2ccccc2/C3=N\C#N)cc(C(F)(F)F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATR Q13535 4/20 0.38
GPBAR1 Q8TDU6 2/20 0.33
PIK3CD O00329 1/20 0.32
PIK3CA P42336 1/20 0.32
PIK3CG P48736 1/20 0.32
MET P08581 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
CTSS P25774 2/20 0.32
MAOB P27338 2/20 0.32
CTSK P43235 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
POLB P06746 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
CYP2C19 P33261 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10075450 0.85 MAOB (0.41) ATRCTSSMAOBCTSKCYP1A2
SCHEMBL10075454 0.81 MAOB (0.41) ATRCTSSMAOBCTSKCYP1A2
SCHEMBL10074506 0.81 ATR (0.38) ATRGPBAR1PIK3CDPIK3CAPIK3CG
SCHEMBL10075448 0.78 MEN1 (0.36) METTDP1CTSSMAOBCTSK
SCHEMBL10074508 0.75 CTSS (0.39) CTSSCTSKPOLBAR
SCHEMBL10074700 0.75 ATR (0.44) ATRMAOBAR
SCHEMBL10050411 0.74 TDP1 (0.37) ATRPIK3CDPIK3CAPIK3CGMET
SCHEMBL10075453 0.74 ADORA2A (0.45) TDP1CTSSMAOBCTSKADORA2A
SCHEMBL10075462 0.72 MYC (0.40) MAOBMEN1CYP1A2POLBCYP2C19
SCHEMBL12248168 0.71 ADORA2A (0.47) ATRTDP1CTSSMAOBCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119828-B2 Material for an organic electroluminescence device and an organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2012-02-21 US disclosed
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-02-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100044686-A1 MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE AFF4, KCNH3, HCN4 ATR 2855/4885GPBAR1 4456/4885PIK3CD 4535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.