⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347594 | 0.79 | — | — | |
| SCHEMBL22300894 | 0.73 | — | — | |
| SCHEMBL1862796 | 0.73 | — | — | |
| SCHEMBL14375669 | 0.69 | — | — | |
| SCHEMBL22582769 | 0.67 | ALDH1A1 (0.46) | — | |
| SCHEMBL23637950 | 0.65 | — | — | |
| SCHEMBL2150283 | 0.65 | ALDH1A1 (0.37) | — | |
| SCHEMBL43433 | 0.65 | — | — | |
| SCHEMBL2222242 | 0.65 | ALDH1A1 (0.37) | — | |
| SCHEMBL2443414 | 0.65 | NOS3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154917-A1 | PHOSPHATE AND PHOSPHONATE BASED COMPOUNDS OF 6-THIO-2'-DEOXYGUANOSINE AS ANTI-CANCER AGENTS | MINGHUI PHARMACEUTICAL (SHANGHAI) LIMITED (CN) | 2020-08-06 | — | — | WO | disclosed |
| US-20180208564-A1 | 1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS | SABILA BIOSCIENCES LLC (US) | 2018-07-26 | — | — | US | disclosed |
| US-20180208584-A1 | 1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS | SABILA BIOSCIENCES LLC (US) | 2018-07-26 | — | — | US | disclosed |
| US-9944630-B1 | Dithiolane carbonate monomers and polymers thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-04-17 | — | — | US | disclosed |
| WO-2014164200-A1 | TYROSINASE INHIBITORS | AVON PRODUCTS, INC (US) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014164195-A1 | TYROSINASE INHIBITORS | AVON PRODUCTS, INC (US) | 2014-10-09 | — | — | WO | disclosed |
| US-8394427-B2 | Paxillin stimulating compositions and cosmetic uses thereof | AVON PRODUCTS, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120328546-A1 | Paxillin Stimulating Compositions and Cosmetic Uses Thereof | AVON PRODUCTS, INC. (US) | 2012-12-27 | — | — | US | disclosed |
| US-8168212-B2 | Topical compositions comprising non-proteogenic amino acids and methods of treating skin | AVON PRODUCTS, INC (US) | 2012-05-01 | — | — | US | disclosed |
| US-20110151029-A1 | Paxillin Stimulating Compositions and Cosmetic Uses Thereof | AVON PRODUCTS, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-20100261769-A1 | Topical Compositions Comprising Non-Proteogenic Amino Acids and Methods of Treating Skin | AVON PRODUCTS, INC. (US) | 2010-10-14 | — | — | US | disclosed |