Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314287 | 0.92 | KDM4E (0.74) | POLBKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL31574569 | 0.90 | POLB (0.68) | POLBKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL14444134 | 0.89 | POLB (0.67) | POLBKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL22420541 | 0.85 | KDM4E (0.66) | POLBKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL22420546 | 0.85 | MAOB (0.72) | POLBKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL3311061 | 0.85 | KDM4E (0.70) | POLBKDM4EALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3319335 | 0.85 | KDM4E (0.70) | POLBKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL10050566 | 0.85 | EGFR (0.64) | KMT2AMEN1L3MBTL1RNF114 | |
| SCHEMBL3313199 | 0.85 | KDM4E (0.75) | POLBKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL3318074 | 0.84 | KDM4E (0.69) | POLBKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150010493-A1 | SMALL MOLECULE INHIBITORS OF RNA SILENCING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-01-08 | — | — | US | disclosed |
| US-20120077804-A1 | Small Molecule Inhibitors of RNA Silencing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-29 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| WO-2009018084-A1 | SMALL MOLECULE INHIBITORS OF RNA SILENCING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | POLB 3681/4885KDM4E 2546/4885ALDH1A1 1386/4885 |
| US-20120077804-A1 | Small Molecule Inhibitors of RNA Silencing | AGO2, EMG1, ZFR | POLB 1860/4885KDM4E 618/4885ALDH1A1 4420/4885 |
| US-20150010493-A1 | SMALL MOLECULE INHIBITORS OF RNA SILENCING | AGO2, EMG1, ZFR | POLB 1860/4885KDM4E 618/4885ALDH1A1 4420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.