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AGO2

Protein argonaute-2 · Q9UKV8 · AGO2 on Sugi Atlas →

2,468 patent compounds predicted against AGO2, 2,090 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Dapsone Dapsone (SCHEMBL2203636) 0.62 2/20
SCHEMBL3290419 SCHEMBL3290419 0.62 2/20
SCHEMBL1179639 SCHEMBL1179639 0.61 2/20
SCHEMBL24407 SCHEMBL24407 0.59 2/20
Zinc Ion Zinc Ion (SCHEMBL192815) 0.59 2/20
SCHEMBL482994 SCHEMBL482994 0.59 2/20
SCHEMBL491612 SCHEMBL491612 0.59 2/20
SCHEMBL514173 SCHEMBL514173 0.59 2/20
SCHEMBL646075 SCHEMBL646075 0.59 2/20
SCHEMBL678391 SCHEMBL678391 0.59 2/20
SCHEMBL759946 SCHEMBL759946 0.59 2/20
SCHEMBL1408800 SCHEMBL1408800 0.59 2/20
Dapsone Dapsone (SCHEMBL2031998) 0.59 2/20
SCHEMBL2289878 SCHEMBL2289878 0.59 2/20
Potassium Ion Potassium Ion (SCHEMBL5776427) 0.59 2/20
SCHEMBL4658355 SCHEMBL4658355 0.57 2/20
SCHEMBL192816 SCHEMBL192816 0.56 2/20
SCHEMBL646074 SCHEMBL646074 0.56 2/20
Lithium Ion Lithium Ion (SCHEMBL1366834) 0.56 2/20
SCHEMBL1367034 SCHEMBL1367034 0.56 2/20

Clinical trials — most relevant to AGO2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis nanCOMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Timisnar - Biomarkers Substudy (Timisnar-mirna) nanUNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Expression Levels of RISC and Microprocessor Complex Components in Epithelial Skin Cancer nanCOMPLETED
microRNA Profile in Early-stage Cervical Cancer nanCOMPLETED
The Andromeda Study.Predictive Value of Combined Criteria to Tailor Breast Cancer Screening. nanCOMPLETED
An In Vivo Model for Postinflammatory Hyperpigmentation nanCOMPLETED
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT nanUNKNOWN
RNA Cloning and Visualization in Human Atherosclerosis nanCOMPLETED
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Search for Bovine miRNA Transference to Humans nanCOMPLETED
Plasma microRNA Levels and Some Cytokines Expression in Patients With ITP Primary Immune Thrombocytopenic Purpura (ITP) nanUNKNOWN
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
X-chromosome Inactivation, Epigenetics and the Transcriptome nanCOMPLETED
Role of Specific microRNAs in Cluster Headache nanRECRUITING
Assessment Of Long Noncoding RNA CCAT1 In Colorectal Cancer Patients nanUNKNOWN
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes nanUNKNOWN
Generating Intervals of Reference FFor Early Life Brain Biomarkers. nanRECRUITING
Risk of HCC in Cirrhotic Patients Post DAAs Ttt nanUNKNOWN
MicroRNAs and Cytokines in Peri-Implantitis Tissue nanUNKNOWN
International PPB/DICER1 Registry nanRECRUITING
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction nanCOMPLETED
Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer nanUNKNOWN
Role of Piwi-protein Interacting RNA, miRNA-194 and Amino Acids in Patients With Prostate Cancer nanUNKNOWN
Cytomegalovirus (CMV) MicroRNA Expression in Vivo and Immune Evasion Correlates nanCOMPLETED
MicroRNA-150 and microRNA-155 in Multiple Sclerosis nanUNKNOWN
Implication of Long Non-coding RNA CCDC144NL-AS1/Micro RNA-143-3p Axis Expression Level as Novel Signature in Colorectal Cancer nanCOMPLETED
Effect of Migalastat on Cardiac Involvement in Fabry Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a AGO2 binder may also engage these)

ProteinNameSimilarity
Q8CJG0 — 1.000 Q8CJG0 →
Q6QME8 — 1.000 Q6QME8 →
Q9QZ81 — 1.000 Q9QZ81 →
Q9H9G7 — 1.000 Q9H9G7 →
Q6DCX2 — 1.000 Q6DCX2 →
Q6DJB9 — 1.000 Q6DJB9 →
Q8CJF9 — 1.000 Q8CJF9 →
Q9UL18 — 1.000 Q9UL18 →
A3KPK0 — 1.000 A3KPK0 →
O77503 — 1.000 O77503 →
Q5ZLG4 — 1.000 Q5ZLG4 →
Q6T5B7 — 1.000 Q6T5B7 →
Q8CJG1 — 1.000 Q8CJG1 →
Q9HCK5 — 0.999 Q9HCK5 →
Q8CJF8 — 0.997 Q8CJF8 →
Q5ZMW0 — 0.997 Q5ZMW0 →
Q4KLV6 — 0.997 Q4KLV6 →
Q9SDG8 — 0.995 Q9SDG8 →
Q5NBN9 — 0.994 Q5NBN9 →
Q9SJK3 — 0.994 Q9SJK3 →
Q0JF58 — 0.993 Q0JF58 →
Q69VD5 — 0.991 Q69VD5 →
Q9VKM1 — 0.991 Q9VKM1 →
Q7Y001 — 0.991 Q7Y001 →
Q6YSJ5 — 0.991 Q6YSJ5 →
Q7XSA2 — 0.990 Q7XSA2 →
Q9XGW1 — 0.989 Q9XGW1 →
Q851R2 — 0.989 Q851R2 →
Q84VQ0 — 0.989 Q84VQ0 →
Q9ZVD5 — 0.989 Q9ZVD5 →