Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15264280 | 0.84 | KDM5A (0.44) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL8160823 | 0.83 | KDM5A (0.46) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL19001333 | 0.80 | KDM5A (0.50) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL9049017 | 0.79 | VNN1 (0.43) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL17185334 | 0.79 | — | — | |
| SCHEMBL10074641 | 0.79 | POLB (0.46) | KDM5AVNN1F10TSHRNPC1 | |
| SCHEMBL19001328 | 0.79 | EPHX2 (0.44) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL10074405 | 0.79 | NPC1 (0.44) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL18701762 | 0.79 | VNN1 (0.46) | KDM5AVNN1F10NPC1RAB9A | |
| SCHEMBL21597921 | 0.78 | F10 (0.43) | KDM5AVNN1F10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | disclosed |