Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.49 |
| ▸ | SDCBP | O00560 | 3/20 | 0.46 |
| ▸ | SDC2 | P34741 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946709 | 1.00 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL4182518 | 1.00 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL22128039 | 0.85 | CYP2C9 (0.41) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL22128037 | 0.85 | CYP2C9 (0.41) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL30569794 | 0.85 | PSMB5 (0.49) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL4195957 | 0.84 | CYP2C9 (0.43) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL4195960 | 0.84 | CYP2C9 (0.43) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 | |
| SCHEMBL4186736 | 0.83 | ALDH1A1 (0.63) | ALDH1A1CYP2C9 | |
| SCHEMBL4186738 | 0.83 | ALDH1A1 (0.63) | ALDH1A1CYP2C9 | |
| SCHEMBL1734627 | 0.83 | PLA2G2A (0.54) | ALDH1A1SMN1; SMN2NPSR1PLA2G2APLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013161980-A1 | CYCLOHEXANEDIAMIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | 東レ株式会社 (JP) | 2013-10-31 | — | — | WO | disclosed |
| EP-1697354-B1 | ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS | MERCK SHARP & DOHME (US) | 2013-08-07 | — | — | EP | disclosed |
| US-8093231-B2 | Sulfonylethyl phosphorodiamidates | TELIK, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20080039429-A1 | SULFONYLETHYL PHOSPHORODIAMIDATES | TELIK, INC. | 2008-02-14 | — | — | US | disclosed |
| US-7262182-B2 | Sulfonylethyl phosphorodiamidates | TELIK, INC. (US) | 2007-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039429-A1 | SULFONYLETHYL PHOSPHORODIAMIDATES | MTAP, TYMP, PHOSPHO1 | ALDH1A1 4455/4885SMN1; SMN2 1097/4885NPSR1 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.