Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.66 |
| ▸ | GRK2 | P25098 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.66 |
| ▸ | MPO | P05164 | 1/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13242436 | 1.00 | CYP3A4 (0.66) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL25272655 | 0.99 | CYP3A4 (0.66) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| SCHEMBL6041369 | 0.80 | REN (0.50) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL15855060 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL1945816 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL8732632 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL1286957 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL10643985 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL27799 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 | |
| Paroxetine SCHEMBL1560678 | 0.79 | CYP3A4 (1.00) | CYP3A4SLC6A4GRK2TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3281628-B1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | NALPROPION PHARMACEUTICALS INC (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20120010232-A1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | OREXIGEN THERAPEUTICS, INC. (US) | 2012-01-12 | — | — | US | disclosed |
| US-20100190793-A1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | OREXIGEN THERAPEUTICS, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| US-7462626-B2 | Compositions for affecting weight loss | OREXIGEN THERAPEUTICS, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| US-7375111-B2 | Compositions for affecting weight loss | OREXIGEN THERAPEUTICS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| EP-1617832-B1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | OREXIGEN THERAPEUTICS INC (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070270450-A1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | OREXIGEN THERAPEUTICS, INC. (US) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190793-A1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | MC4R, MC3R, MC5R | CYP3A4 3921/4885SLC6A4 978/4885GRK2 100/4885 |
| US-20120010232-A1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | MC4R, MC3R, MC5R | CYP3A4 3921/4885SLC6A4 978/4885GRK2 100/4885 |
| US-20070270450-A1 | COMPOSITIONS FOR AFFECTING WEIGHT LOSS | MC4R, MC3R, MC5R | CYP3A4 3921/4885SLC6A4 978/4885GRK2 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.