Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 4/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | GLB1 | P16278 | 1/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12609037 | 0.88 | ARG1 (0.47) | DRD3SLC6A3ARG1DPP4 | |
| SCHEMBL3780786 | 0.85 | ARG1 (0.58) | DRD3SLC6A3ARG1ALOX5DPP4 | |
| SCHEMBL4867875 | 0.85 | ARG1 (0.58) | DRD3SLC6A3ARG1ALOX5DPP4 | |
| SCHEMBL3787271 | 0.79 | ARG1 (0.60) | ARG1DPP4S1PR3ALDH1A1GLB1 | |
| SCHEMBL5511790 | 0.79 | ARG1 (0.60) | ARG1DPP4S1PR3ALDH1A1GLB1 | |
| SCHEMBL10237781 | 0.77 | ARG1 (0.41) | DRD3SLC6A3ARG1DPP4ALDH1A1 | |
| SCHEMBL15221802 | 0.74 | DPP4 (0.44) | ARG1DPP4 | |
| SCHEMBL14628659 | 0.74 | DPP4 (0.44) | ARG1DPP4 | |
| SCHEMBL14628660 | 0.74 | DPP4 (0.44) | ARG1DPP4 | |
| SCHEMBL8294074 | 0.73 | ARG1 (0.40) | ARG1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468744-A2 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-27 | — | — | EP | disclosed |