Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | MC3R | P41968 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.63 |
| ▸ | PTGFR | P43088 | 4/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473293 | 0.87 | PDE4D (0.69) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL14968511 | 0.86 | ALDH1A1 (0.56) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL16613944 | 0.83 | PDE4D (0.61) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903202 | 0.82 | PDE4D (0.78) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903200 | 0.82 | PDE4D (0.78) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903428 | 0.81 | PDE4D (0.84) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903423 | 0.81 | PDE4D (0.84) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL18388401 | 0.81 | PDE4D (0.84) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL7952226 | 0.81 | PDE4D (0.58) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL7952228 | 0.81 | PDE4D (0.58) | PDE4DPGRADORA3ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012282-A1 | BIFUNCTIONAL RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |