Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 1.00 |
| ▸ | GAA | P10253 | 12/20 | 1.00 |
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | POLB | P06746 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | GFER | P55789 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | BLM | P54132 | 3/20 | 0.78 |
| ▸ | PLEC | Q15149 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077924 | 0.91 | MAPT (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL10077846 | 0.89 | MAPT (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL10077848 | 0.87 | MAPT (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL10077845 | 0.87 | GAA (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL10077002 | 0.85 | MAPT (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL10077844 | 0.83 | MAPT (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL13166883 | 0.73 | MST1R (1.00) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL5646856 | 0.72 | TP53 (0.69) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL17481572 | 0.72 | KMT2A (0.56) | MAPTGAAMEN1KMT2APOLB | |
| SCHEMBL6698946 | 0.70 | MAPT (1.00) | MAPTGAAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |